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KMID : 0359320130530030169
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Korean Journal of Veterinary Research
2013 Volume.53 No. 3 p.169 ~ p.174
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Protective effects of a mineral aqueous solution on toxicity in mouse liver and kidney
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Park In-Jae
Cha Se-Yeoun
Kang Min
So Yang-Sub
Bahng Ji-Yun
Jang Hyung-Kwan
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Abstract
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We demonstrated that a mineral aqueous solution (MAS) administered to mice functionally and histologically protected against cisplatin-induced acute renal failure (ARF) and CCl4-induced acute liver failure (ALF). In ARF model, 0.4 and 0.2% MAS decreased mortality and the serum concentrations of blood urea nitrogen (BUN) and creatine in mice. Additionally, 0.4 and 0.2% MAS reduced contraction of distal convoluted tubules and suppressed expression of the proinflammatory cytokines interlukein-6 (IL-6) and tumor necrosis factor (TNF-α) in the kidney. In ALF model, 0.4 and 0.2% MAS decreased serum concentrations of alanine aminotransferase and aspartate aminotransferase in mice. Additionally, 0.4 and 0.2% MAS reduced necrotic areas and suppressed expression of IL-6 and TNF-α in the liver. These results indicate that a MAS might have protective effects against ARF and ALF.
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KEYWORD
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CCl4-induced acute liver failure, cisplatin-induced acute renal failure, mineral aqueous solution, silicon
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